1. Coronavirus: Australia extends travel ban on people entering from China for a week
  2. Football transfer rumours: Sancho to Chelsea or Manchester United?
  3. Australia weather: Rain could put out remaining New South Wales blazes
  4. Teenagers are the hardest part of parenting. But that’s only half the story
  5. Sinn Fein votes to abandon abstentionism and fight for seats in the Dail – archive, 1986
  6. David Moyes admits West Ham could lose Declan Rice in the summer
  7. Experience: I get drunk without drinking
  8. Nike stirs the pot with ‘gamechanger’ running shoe in step with new rules
  9. Russian priests shouldn’t bless nuclear weapons, other weapons of mass destruction, Orthodox Church says
  10. Guardian sport’s Suzanne Wrack honoured at AIPS Media Awards
  11. Malawi election: Court to rule on 2019 presidential poll
  12. As the world loses faith in democracy, leaders of vision are desperately needed
  13. Transfer window verdict: how every Premier League club fared in January
  14. The best apps to get fit with your friends: from Fitbit to Strava The best apps to get fit with your friends: from Fitbit to Strava
  15. Kobe Bryant brilliance, Super Bowl showreels and Six Nations memories
  16. UK has chance to relook at Huawei 5G decision, says Pompeo
  17. Coronavirus: Death toll climbs to 106 as China tightens measures
  18. Woman dies in Australian Day lamington-eating contest
  19. England in South Africa: Mark Wood shines in Johannesburg
  20. Gary Neville asks right questions of Qatar but gets no nearer answers we need
  21. Sex is for married heterosexual couples only, says Church of England
  22. Landlords back cards for EU citizens to prove post-Brexit status
  23. Sergio Agüero’s tap-in for Manchester City breaks Sheffield United barrier
  24. Roberta Flack: ‘My music is my expression of what I feel in a moment’ Roberta Flack: ‘My music is my expression of what I feel in a moment’
  25. Boris Johnson urged to publish report on Russian meddling
  26. Alan Dershowitz: Trump impeachment acquittal would make me unhappy
  27. Minnesota voters cast first ballots of 2020 election
  28. The Iowa caucuses are three weeks away – and there’s no clear frontrunner
  29. From the Oscars to the Democratic party: why are US culture and politics still so white?
  30. Democrats draw battle lines in Iowa
  31. Barcelona appoint Quique Setién as head coach to replace Ernesto Valverde
  32. ‘It means you’re going to lose’: Bernie Sanders answers Trump on rise in polls
  33. My Oscar goes to… our film critics reveal their personal shortlists My Oscar goes to… our film critics reveal their personal shortlists
  34. Harry and Meghan face potential fight to protect ‘Sussex Royal’ brand
  35. Inter offer £3.4m for Olivier Giroud but Chelsea holding out for £8.5m
  36. Irregular migration to EU at lowest level since 2013 – border agency
  37. Carlos Ghosn: Nissan inquiry a ‘gross perversion’
  38. Rory Burns to miss England’s tour of Sri Lanka after undergoing ankle surgery
  39. Apocalypse now-ish: what can we learn from films set in 2020?
  40. Chelsea complete Reading comeback win in Sam Kerr’s promising debut
  41. Marnus Labuschagne double ton hands Australia healthy lead
  42. Ian Holloway: ‘It’s always about the team and the togetherness’ Ian Holloway: ‘It’s always about the team and the togetherness’
  43. The Fiver Christmas Awards 2019 The Fiver Christmas Awards 2019
  44. Body fat recordings and mood scores: has technology gone too far in rugby?
  45. Ex-Google exec Ross LaJeunesse savages firm on human rights
  46. More than 200 members of Congress urge US supreme court to reconsider Roe v Wade
  47. Liberia’s miracle oil brings farmers only empty promises
  48. Heartbreaking photos show migrants traveling through Bosnia in search of a better life
  49. Kyrgios, Stosur and others pledge $200 per ace to bushfire relief efforts
  50. NFL probe has not implicated Bill Belichick, football staff in Patriots’ sideline video of Bengals
  51. ‘The salt they pump back in kills everything’: is the cost of Chile’s fresh water too high? ‘The salt they pump back in kills everything’: is the cost of Chile’s fresh water too high?
  52. Hillary Clinton appointed chancellor of Queen’s University, Belfast
  53. This decade belonged to China. So will the next one
  54. Wickham evens it up for Crystal Palace as Norwich lose early lead again
  55. Referee Bobby Madley reveals ‘dark joke’ that led to Premier League sack
  56. The Guardian view on internet censorship: when access is denied
  57. Game of Thrones: how it dominated the decade – then lost its way Game of Thrones: how it dominated the decade – then lost its way
  58. Man charged over damage to £20m Picasso at Tate Modern
  59. ‘Time for a fresh start’: Nigel Wray retires as Saracens chairman
  60. Mike Pompeo to visit Ukraine ahead of Trump impeachment trial
  61. The plastic polluters won 2019 – and we’re running out of time to stop them The plastic polluters won 2019 – and we’re running out of time to stop them
  62. Italian PM calls for unity as three senators move to far right
  63. These bushfires are a historic event. Here is what we should learn from them
  64. Chris Packham: ‘I don’t look for conflict, but I won’t shy away’ Chris Packham: ‘I don’t look for conflict, but I won’t shy away’
  65. Kataib Hezbollah: Iraq condemns US attacks on Iran-backed militia
  66. Record number of over-45s giving birth in England
  67. West Ham put four past Bournemouth to welcome back David Moyes in style
  68. Of course Trump hates central bankers – they tell the truth
  69. Allee Willis obituary
  70. Telusa Veainu completes Leicester’s comeback for draw against Harlequins
  71. Meet Focus Group Man: the most unlikely meme of 2019
  72. The Spin’s Test team of the decade, from Cook to Anderson via Kohli
  73. The only way to fight antisemitism is solidarity and compassion – not division
  74. Mexico authorities arrest police chief on suspicion of link to cartel massacre that killed 9 Americans
  75. Italy avalanches kill 4 in 24 hours, including woman and 2 girls
  76. Eli Manning looks to uncertain future after likely New York Giants farewell
  77. Conor Hourihane edges Aston Villa past Norwich in drop-zone battle
  78. Why 2019 was a landmark year for disabled fashion
  79. The power behind the thrones: 10 political movers and shakers who will shape 2020 The power behind the thrones: 10 political movers and shakers who will shape 2020
  80. Allee Willis: Friends theme songwriter dies at 72
  81. Oh, do give Boris Johnson a break. After all he’ll do for us, why shouldn’t he jet off to Mustique?
  82. This was the decade America’s self-serving myths fell apart
  83. Russia ‘successfully tests’ its unplugged internet
  84. Rental house suffers $50G in damage during party: ‘All the windows of the house had been smashed’
  85. Ring sued by man who claims camera was hacked and used to harass his kids
  86. Manchester United’s deadly Anthony Martial punishes sloppy Burnley
  87. ‘I win’: David Moyes defends record and plans to stick around at West Ham
  88. ‘As an editor, she didn’t worry about breaking conventions’: Deborah Orr remembered
  89. CCTV installed at Karl Marx’s grave in Highgate cemetery
  90. Marathon efforts are increasingly normalised so cheats are trying to keep up
  91. Alasdair Gray, influential Scottish writer and artist, dies aged 85
  92. Pope Francis warns of ‘rigidity,’ says church must adapt or it will become increasingly irrelevant
  93. Eli Winter: discover the young folk guitarist making sense of loss
  94. Dora Maar’s Portrait of Ubu: soft-skinned alien
  95. Saudi Arabia hands down 5 death sentences for Khashoggi’s killing, state TV says
  96. Pep Guardiola says replacing Sergio Agüero will be one of his toughest jobs
  97. Harry Kane rescues point for Spurs at Norwich after Aurier’s farcical own goal
  98. UK weather ‘attracts migrant species but threatens native ones’
  99. Seven die in landslide in Brazilian city of Recife
  100. ‘Nothing is impossible’: Everton’s Carlo Ancelotti targets Anfield FA Cup win
  101. Sixteen-year-old Shah bowls Pakistan to first home Test series win since 2006
  102. Jamie Maclaren hits hat-trick as Socceroos stroll to win over Nepal
  103. Art Briles’ high school team could be forced to forfeit games due to ineligible players
  104. 2019 MLB playoff schedule: Dates, TV channels for postseason, World Series
  105. 2009 Christmas Day underwear bomb maker killed, White House confirms
  106. ‘Best player in the world’: Inside Kawhi Leonard’s Thursday night Clippers debut
  107. ‘If you believe what it says, we’re all stuffed’: the Latin funeral song haunting soundtracks
  108. Coleen Rooney, Rebekah Vardy social media fiasco, explained
  109. OECD aims to stop tech firms shifting profits to low-tax locations
  110. Fantasy football rankings for Week 6: Deshaun Watson is no passing fancy
  111. Economics Nobel prize won by academics for tackling poverty
  112. High school football player tackled teammate after interception was returned the wrong way
  113. Homeward bound: The lesser known lights who shone in World Cup pool stages
  114. Catalan separatist leaders given lengthy prison sentences
  115. American lawyer serving as Micronesia’s assistant AG shot dead while returning home from run
  116. Why films about learning disabilities need to be more than merely feelgood
  117. Why is it that when I fall asleep watching TV, I wake up just in time for the credits?
  118. Trump rallies in Louisiana in last-minute push for governor’s race
  119. Ambassador’s removal: ‘deeply concerning’ Rep. Jim Himes
  120. Michael Cheika bites back at Eddie Jones before Rugby World Cup quarters
  121. Ireland face Samoa needing bonus-point win amid concerns about pitch
  122. Race for top draft pick heats up when Dolphins face Redskins
  123. ‘It was almost impossible’: Thai cave rescue finally gets its first film
  124. With China rift ongoing, NBA says free speech remains vital
  125. Your pictures: share your photos on the theme of ‘hypnotic’
  126. Opinion: US gymnast Sunisa Lee finds herself balancing highs and lows at world championships
  127. US-N. Korea nuclear talks, weather in the South, Hong Kong violence: 5 things you need to know this weekend
  128. Driver nearly killed teen in road rage crash, police say. He faces a fine
  129. Alexander Downer: the Australian blue blood accused of being an anti-Trump ‘spy’
  130. Deadly fungi native to Japan and Korea discovered in Australian rainforest
  131. Vontaze Burfict suspended for rest of NFL season for late hit on Colts TE Jack Doyle
  132. Russian actor Ustinov has jail sentence reduced on appeal
  133. SEC power rankings: What to do with Texas A&M? Just how good is Auburn?
  134. Hamilton leads Mercedes one-two finish at Russian Grand Prix
  135. 12-year-old with epilepsy pushes Washington DC to change medical marijuana policy
  136. Forget ‘any given Sunday’: There are givens in NFL this year
  137. Boris Johnson urged to calm Commons ‘inferno of rhetoric’
  138. ‘The times have found us’: Nancy Pelosi’s decision to support an impeachment inquiry, annotated
  139. Raheem Sterling leads Manchester City’s safe passage at Preston
  140. Healthy Erik Karlsson key to Sharks’ success this season
  141. Liverpool 5 points clear at top after beating Chelsea 2-1
  142. Braves beat Giants 6-0, clinch 2nd straight NL East title
  143. Spotlight on Jalen Ramsey, Jaguars’ decline during Thursday night’s game vs. Titans
  144. No. 13 Wisconsin to host No. 11 Michigan in Big Ten clash
  145. Irish businessman abducted and assaulted in ‘horrific attack’
  146. Javier Burillo: Mexican property developer held over son’s boating death
  147. Dolphins’ odds of winning Super Bowl now 20,000 to 1
  148. Paxton wins 9th straight start as Yankees rout Jays 13-3
  149. Busted flush: gold toilet stolen from Blenheim Palace
  150. More injury woes for Yankees in doubleheader sweep of Tigers
  151. Report: Triple Crown winner Justify failed a drug test weeks before the Kentucky Derby
  152. Nigeria detained children as young as five over ‘Boko Haram links’ – report
  153. Grisham has 5 hits, Brewers top Marlins for 4th straight win
  154. US removed covert source in Russia due to safety concerns under Trump – report
  155. Ravens rookie Marquise Brown scores 2 touchdowns on first 2 NFL catches
  156. Diamondbacks extend surge, beat Reds 7-5 behind Marte
  157. Bears’ offense struggles in opening loss to Packers
  158. The Upside escapes Brexit for the continent
  159. DeSean Jackson hyped for his first game back with Eagles
  160. Rafael Nadal rolls into U.S. Open semifinals with straight-set win over Diego Schwartzman
  161. French court rules Maurice the noisy cockerel can keep crowing
  162. Jon Gruden kept 12 rookies on Oakland Raiders’ roster, but not one ‘Hard Knocks’ star
  163. Politician scolds female professor for not having child
  164. Personal assistant’s departure ‘automatic’ after making ‘hurtful’ comments: Trump
  165. Gold Star families desperate for tax fix as Congress returns from recess
  166. Jets’ Le’Veon Bell ready for big workload in return to action: ‘Don’t hold back’
  167. I’d been too scared to sing since childhood – could I find my voice? I’d been too scared to sing since childhood – could I find my voice?
  168. Jon Gruden kept 12 rookies on Oakland Raiders’ roster, but not one ‘Hard Knocks’ star
  169. We know how Johnson wants to play this election. The signs are it’s not working
  170. Canned applause: why tinned food isn’t just for Brexit
  171. Show me the mummy: the undying allure of ancient Egypt
  172. Malaria breakthrough as scientists find ‘highly effective’ way to kill parasite
  173. Trade war could jeopardize economic growth: Sen. Pat Toomey
  174. TV tonight: an unrecognisable Russell Crowe plays the tyrant of Fox News TV tonight: an unrecognisable Russell Crowe plays the tyrant of Fox News
  175. Israeli military kills 3 Palestinians near Gaza fence after firing toward ‘armed suspects,’ officials say
  176. FC Dallas overcomes 3-goal deficit to tie Impact
  177. Peter Fonda, star of Easy Rider, dies aged 79
  178. OnPolitics: Trump vs. everybody
  179. AFLW star Tayla Harris extends unbeaten professional boxing record
  180. Michigan’s Harbaugh says he wouldn’t lie about transfer
  181. Hong Kong airport reopens as Trudeau urges China to address ‘serious concerns’
  182. Drug maker ‘will make $21bn from treating cystic fibrosis’
  183. Mahomes sharp as Chiefs rout Bengals in preseason opener
  184. Former Panama President Martinelli not guilty of corruption
  185. US arrests 680 workers in immigration sting before Trump visits El Paso
  186. Zuleika Hassan: Kenyan MP with baby ordered to leave parliament
  187. Catalans’ Kenny Edwards charged with incitement after crowd trouble
  188. Brazil drug dealer dresses up as daughter in bungled jail escape
  189. I was a ladder-climbing journalist. Now I’m a childless househusband – and I love it
  190. Crackdown on Moscow protest suggests new approach against opposition
  191. Russian Instagram influencer’s ex-boyfriend arrested, confesses to murder in police video
  192. As the Netherlands’ burqa ban takes effect, police and transport officials refuse to enforce it
  193. Bahrain urged to halt imminent execution of two men
  194. Air strike on Libya hospital kills five doctors
  195. Georgia buys new voting machines amid challenge to old ones
  196. US teenager wins $3m playing computer game Fortnite
  197. Brittney Griner dunks, Erica Wheeler named MVP in record-setting WNBA All-Star Game
  198. Supreme Court allows border wall spending in battle between President Donald Trump and liberal opponents
  199. Daniele De Rossi completes move to Boca Juniors after 18 years at Roma
  200. Tesla shares fall after company again reports larger than expected loss
  201. 3-year-old boy hit by foul ball off bat of Indians’ Francisco Lindor ‘doing well’
  202. Venezuela blackout: Power cuts plunge country into darkness
  203. Former tennis star Peter McNamara dies aged 64
  204. Herschel Jantjies leads South Africa past Australia with debut double
  205. South Africa’s President Cyril Ramaphosa accused in corruption row
  206. Cats movie trailer: internet reacts in horror to ‘demented dream ballet’
  207. Amnesty International calls for closure of migrant child detention center
  208. Trump administration to continue deporting Venezuelans despite crisis
  209. China’s commerce minister, joining trade talks, says there’s need to ‘uphold our warrior spirit’
  210. Death of ‘barefoot lawyer’ puts focus on China’s treatment of political prisoners
  211. The big picture: New York with ladies and luggage The big picture: New York with ladies and luggage
  212. Murphy’s homer in 8th helps Rockies beat Reds 3-2
  213. Italy frees man wrongly extradited for people smuggling
  214. Chinese police crack down on bitcoin miners over $3m of stolen electricity
  215. One thing every MLB team needs to do in the second half
  216. Are we alone? Nearly 400K people have signed up for Facebook event to ‘storm’ Area 51 and ‘see them aliens’
  217. Tommy Robinson given nine-month jail term for contempt of court
  218. Google workers can listen to what people say to its AI home devices
  219. Patriots linebacker Elandon Roberts says he was harassed at home by police
  220. When is fruit ready to pick? Nature offers different clues
  221. Texas woman shares home with mother’s corpse for three years
  222. A California school board has voted to paint over a mural of George Washington. Educators want to save it
  223. Football player paralyzed during Georgia game receives wheelchair-accessible home
  224. Australia are the hunters turned the hunted in Netball World Cup
  225. One high school fired a gay teacher. Another school protected one. They are married to each other
  226. Flooded New Orleans braces for possible hurricane
  227. Australia catamaran accident leaves three people dead
  228. The Philippines sided with China after a boat was rammed. Critics say it’s all about money. 
  229. Who’s running for president in 2020?
  230. How Iran’s ‘filmfarsi’ remains the biggest secret in cinema history How Iran’s ‘filmfarsi’ remains the biggest secret in cinema history
  231. Abortion support is the highest it’s been in two decades as challenges mount
  232. Opinion: Megan Rapinoe embodies all the swagger, fearlessness of the US World Cup team
  233. Appeals court sides with President Trump, dismisses ’emoluments’ lawsuit involving his DC hotel
  234. The U.S. begins returning asylum seekers to one of Mexico’s most dangerous states
  235. Charity benefiting from strip club golf tournament at Trump’s Doral pulls out of event
  236. California takes on surprise bills, over hospital objections
  237. Kawhi Leonard and Paul George officially join Los Angeles Clippers
  238. Arizona teacher may have been grooming other students for sex, report shows
  239. Pope during Easter vigil: reject the ‘glitter of wealth’
  240. Israeli election may have dimmed hopes for 2-state solution
  241. Extinction Rebellion: Climate protesters ‘making a difference’
  242. Boxing is leaving Amir Khan behind after Terence Crawford defeat
  243. All the president’s men and women: how disobedient aides saved Trump
  244. Delphi murders: Police release video of suspect in teens’ murders in 2017
  245. Ugandan police detain Bobi Wine and fire teargas at supporters
  246. Robbie Fowler says coaching Brisbane Roar ‘is a massive opportunity’
  247. The Latest: EU regrets US decision on Iran sanctions
  248. Oil prices surge to six-month high as US gets tough on Iran embargo
  249. Opinion: Joel Embiid and Ben Simmons play like 76ers cornerstones they need to be
  250. Lamoriello, Trotz orchestrate Islanders’ big turnaround
  251. 2019 Buffalo Bills schedule includes rare Thanksgiving game vs. Dallas Cowboys
  252. Sri Lanka bombing victims were from at least 12 countries
  253. After guarantee, Sharks’ Tomas Hertl forces Game 7 vs. Golden Knights with double-OT goal
  254. Japan sterilisation law victims get compensation and apology
  255. Football transfer rumours: Niklas Sule to Manchester United for £50m?
  256. Doctor: Alabama’s Saban undergoes hip replacement surgery
  257. Abreu HR, 5 RBIs helps White Sox crush Orioles 12-2
  258. Rodrigo de Lima: UFC fighter killed at 26 after alleged dispute with rideshare driver
  259. North Korea says it test-fired new tactical guided weapon
  260. Stanley Cup playoffs 2019: Capitals make lineup changes ahead of Game 5; DSP returns
  261. Trump policy of less safety and more offshore drilling is ‘a recipe for disaster’
  262. ‘Giant lion’ fossil found in Kenya museum drawer
  263. Attorney General William Barr faces a political firestorm after release of the Mueller report
  264. AP/CP survey: NHL players dislike delay of game rule
  265. Ukraine election: The president vs. guy who plays one on TV
  266. ‘Rebrand’ the Boeing 737 Max? Who is Trump trying to trick?
  267. C.T. Pan rallies to win RBC Heritage for 1st PGA Tour title
  268. Somerset see off Sussex after rain curtails James Hildreth’s big day
  269. Hamels pitches 7 innings, Cubs complete sweep with 6-0 win
  270. Italian broadcaster’s plans for gender-based channels spark fury
  271. Kelsey Lu: Blood review – inventive, crystalline debut of a pop auteur
  272. ‘Spurs are still in a dream,’ says Mauricio Pochettino after triumph over City
  273. Major tracks to ban race-day use of anti-bleeding medication
  274. Understated as always, Nicklas Backstrom delivers for Capitals in Game 5
  275. Mueller’s report paints a damning portrait of Trump’s presidency
  276. Vladimir Putin’s team doesn’t like Robert Mueller’s report on election interference, Trump
  277. Legendary UNC basketball coach resigns after investigation into program
  278. Pelosi says Democrats can hold Trump accountable without impeachment hearings
  279. Supreme Court takes on LGBT employment discrimination
  280. Sen. Elizabeth Warren promises to roll back Trump energy policies on 1st day in office
  281. Presidential candidate Wayne Messam’s lawyers reviewing allegations campaign team didn’t get paid
  282. FACT CHECK FRIDAY: The Mueller Edition
  283. Top Republican on House Judiciary urges Democrats to view less-redacted special-counsel report
  284. ‘American Idol’: Wade Cota’s unique spin on ‘Toy Story’ classic is Disney Night highlight
  285. For Warren, there is no criminal justice reform without addressing racism
  286. Wolves v Brighton: match preview
  287. Kim Jong Un to meet Vladimir Putin as North Korea pivots to Russia for help
  288. Matthews, Kapanen score late, Maple Leafs edge Bruins 2-1
  289. Jussie Smollett case: Brothers accused of carrying out attack sue actor’s legal team for defamation
  290. Air Force Academy instructor charged with ‘internet luring of a child’
  291. Felons, plastic surgery and 13 women dead
  292. Pitcher Michael Wacha goes on Cardinals’ injured list
  293. Sri Lanka caught off-guard by attacks despite its violent recent past
  294. Oops: Gavin DeGraw face plants after national anthem before Game 5 between Predators and Stars
  295. Trump blames McGahn after Mueller paints damning portrait with notes from White House aides
  296. What made Jim Davidson a living legend?
  297. Mueller report: President Trump tried to impede Russia inquiry but aides ignored his orders
  298. Sen. Kamala D. Harris expresses ‘regret’ over her California truancy policy
  299. On Capitol Hill, some Trump officials are testifying for an audience of one
  300. Trump investigations and gun coverage shine in 2019 Pulitzer Prizes
  301. Pete Buttigieg says he can beat Donald Trump in 2020
  302. Yes, Virginia! At Scott Stadium, about 21,000 Cavaliers faithful embrace national champs.
  303. Cozart, La Stella lead Angels past Cubs 6-5
  304. Exclusive trailer: Springsteen, Van Zandt headline documentary on ‘Asbury Park’ sound
  305. House Democrats to subpoena accounting firm for Trump’s financial records
  306. Trump to visit Normandy for 75th anniversary of D-Day
  307. A ‘pure racist act;’ N.Y. Post slammed for using 9/11 to attack Rep. Omar over speech on Islamophobia
  308. Five not-so-typical ways to fight your allergies
  309. Kids are ordering so much delivery for lunch, these schools are banning it
  310. Republicans to Trump: Your immigration shake-up makes no sense
  311. Richard Cole, last surviving member of the Doolittle Raiders, dies at 103 in Texas
  312. PG Tre Jones to return to Duke for sophomore season
  313. Drinks at 11pm? How to tell if you are the victim of EMG
  314. Orioles Chris Davis nearing record futility steaks
  315. Arab Israeli candidates launch last-ditch effort against Netanyahu and voter disillusionment
  316. ‘Are you enjoying your city break?’ my wife says
  317. Belt homers to spark Giants offense in 6-4 win over Rays
  318. Ex-spy Valerie Plame eyeing return to Washington — as a member of Congress
  319. Trump lawyer calls on Treasury to reject Democrats’ demand for tax returns until Justice Department weighs in
  320. TV and radio listings: March 31
  321. ‘I’m agnostic’: Pelosi questions whether Medicare-for-all can deliver benefits of Obamacare
  322. How Brie Larson tackles subtle sexual harassment in Netflix’s ‘Unicorn Store’
  323. Brexit: MPs back delay bill by one vote
  324. Michelle Williams felt ‘paralyzed’ after learning of pay gap between her and co-star Mark Wahlberg
  325. Rep. Gaetz says transgender rights bill would let Trump declare himself the ‘first female president’
  326. ‘Where are all the black women in grime? The same place they are in the rest of the music industry – sidelined’
  327. Not So Obvious: Reasons to Love And Admire Jim Davidson
  328. Opinion: Stumbling Thunder just can’t get out of their own way as playoffs loom
  329. Natalia Fileva: Russia airline co-owner dies in private jet crash
  330. 5 Unbelievable Facts About Jim Davidson
  331. Mueller’s report is a warning – and Britain won’t listen
  332. Rock and Roll Hall of Fame 2019: Everything you missed from the induction ceremony
  333. Tennessee’s Mariah Smith has power to inspire others at Augusta National Women’s Amateur
  334. Mexican Navy: 1 injured in clash near vaquita reserve
  335. Shia LaBeouf, Tom Hiddleston and Daniel Craig reveal the toll of the role
  336. Why Special Olympics gets federal money: It runs school programs – & has presidential ties
  337. Ex-Trump aide details president’s alleged effort to cover up the Trump Tower meeting
  338. What separates this Virginia team from its NCAA busts? NBA talent.
  339. Murray stays unbeaten in NYC as Penguins top Rangers 5-2
  340. Rangers down to 1 roster spot after claiming Rule 5 pitcher
  341. ‘Job is not done yet’: Virginia rides emotional roller coaster into Sweet 16
  342. Woods to open Match Play against PGA Tour rookie of year
  343. March Madness: No. 1 Duke barely holds off Central Florida at buzzer in classic game
  344. Algerian president’s party rejects his protest strategy
  345. For first time, a woman won Afghanistan’s version of ‘American Idol’
  346. Dozens of Mali villagers killed by gunmen
  347. In wake of deadly cyclone in Mozambique, a hunt for bodies and long wait for aid
  348. Brexit’s biggest impact on rugby league is likely to be financial
  349. Troy Brown Jr. keeps getting called ‘Tony.’ A bigger role with the Wizards might change that.
  350. China chemical blast: Survivor found but toll rises again
  351. As large-market teams chase stars or tank, Pacers take a moderate approach
  352. Fatal police shooting of Beth Plant, mother of boxer Caleb Plant, deemed ‘justified’
  353. China chemical blast: Survivor found but toll rises again
  354. Attorney general could release ‘principal conclusions’ of Mueller report as early as today
  355. Timeline: Key events since Thailand’s last general election
  356. Chris Sale agrees to a five-year, $145 million extension with Red Sox
  357. Euro 2020 qualifiers and international football: 10 things to look out for Euro 2020 qualifiers and international football: 10 things to look out for
  358. Here’s how to stream the 2019 NCAA tournament to watch March Madness
  359. ’He’s ready’: Max Scherzer is in mideason form in final spring start, striking out 12 Marlins
  360. ‘A family against a billionaire’: twist in battle over Zuckerberg’s Hawaiian estate
  361. How Luton lost a manager but continue to soar under Mick Harford
  362. Talking Horses: Jason Watson back in the saddle for Flat turf campaign
  363. Trent Alexander-Arnold out of England Euro 2020 qualifiers with injury
  364. In China, Apple’s Cook says he’s bullish on global economy
  365. Donald Trump and Xi Jinping are missing a trick over trade
  366. March Madness: Liberty dances past Mississippi State; North Carolina tops Iona
  367. EU leaders postpone decision on 2050 climate goal
  368. Odd surprise, lots of top NBA talent left in NCAA Tournament
  369. May tells Johnson: I will not step aside to solve Brexit crisis
  370. Peter Beardsley charged by FA with using racist language towards youth players
  371. Huge chemical blast kills at least 47, injures hundreds in eastern China
  372. Dominic Calvert-Lewin scores but England Under-21s draw with Poland
  373. Tall Fall leads ninth-seeded UCF to first NCAA win over VCU
  374. New Thai government may be unstable, short-lived
  375. North Korea pulls out of liaison office with the South in blow to warming ties
  376. Christchurch attack: Al Noor mosque handed back to Muslim community
  377. NCAA, major conferences ask 9th Circuit to overturn ruling on cap for athlete compensation
  378. Robert Kraft files motion to keep Orchids of Asia Day Spa videos from becoming public
  379. Schumer meets with Stacey Abrams about possible Senate bid for Georgia seat
  380. Okwui Enwezor: the Nigerian who confronted the European art canon
  381. Okwui Enwezor: the Nigerian who confronted the European art canon
  382. Talking Horses: Jason Watson back in the saddle for Flat turf campaign
  383. Christchurch attacks: Al-Noor mosque reopens to worshippers
  384. Venezuelan intelligence unit detains chief of staff of opposition leader Juan Guaidó
  385. Five ways that New Zealand showed solidarity with its tiny Muslim community this week.
  386. Clues to the identity of Iran’s next supreme leader in the back alleys of a holy city
  387. Inside Stuttgart: a fallen giant in search of a fresh-faced identity Inside Stuttgart: a fallen giant in search of a fresh-faced identity
  388. German journalist who gave birth as hostage in Syria speaks of ordeal
  389. The Joy of Six: classic Germany v Netherlands encounters
  390. Ex-Philippine officials accuse Xi of crimes against humanity
  391. Report: Sydney Aiello, who survived the Parkland high school shooting, dies by suicide
  392. Trump escalates attacks on John McCain, says never got a ‘thank you’ for approving late senator’s funeral
  393. Hungarian prime minister earns rare rebuke from European bloc that has long backed him
  394. Thai parties hold final campaign rallies before election
  395. Barclays deal shows women’s game now big-bucks business
  396. March Madness: Don’t make these five mistakes in your NCAA tournament bracket
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A ALL OF US company, that is refusing shed its cost for the life-changing cystic fibrosis drug Orkambi to make it inexpensive to NHS England, is placed to make $21bn (£17bn) within profit from might a sibling medicine, based on research.

Nations around the world are usually struggling to fund Orkambi, produced by Vertex, that has a list associated with £104, 1000 per affected person per year and it is not a treatment. The Nationwide Institute associated with Health and Treatment Excellence (Nice) in England reports it is not economical. On Mon, the Scottish Medicines Range will determine whether in order to approve the particular drug with regard to children.

Mother and father in England possess campaigned, shown on the roads and pleaded for their kids with cystic fibrosis to become allowed Orkambi for more compared to three years because it was certified. Vertex states it has spent billions within research, made a reduction and requires a price that will enable it to purchase future medicines for the condition.

But an investigation paper simply by Aidan Hollis, professor associated with economics on Calgary College in Europe, disputes that will. It approximated that Vertex will make $21. 1bn within profit on the lifetime of Orkambi and an early on drug known as Kalydeco that can be found on the NHS but goodies only a little proportion associated with patients.

Earlier funding just for research in to the two medicines came from the cystic fibrosis foundation in america, which obtained a royals on upcoming profits in return. That was purchased by a firm called Royals Pharma within 2013 pertaining to $3. 3bn. Hollis computed in his document, shortly to become published within the journal Health care Policy, which the anticipated upcoming profits during those times were $33bn. Deducting Vertex’s costs, this individual calculates the particular figure to become $21. 1bn.

“They are usually earning revenue on all those drugs. There is absolutely no question about this compared to the actual put in, ” Hollissaid.

Vertex argues it offers invested $11. 8bn within the research and development associated with cystic fibrosis drugs, however said Hollis, that was a technique for making more income.

“You place all this cash into R&D because it continues to be enormously rewarding for you and also you think you are likely to be able to cost a lot of money later on. If you choose to period money plus reinvest this in some thing, it does not mean a person didn’t create profits, ” said Hollis.

Pharma watchers believe the particular strategy are going to pay off. Vertex is making a triple mixture drug, including two from the medicines currently on the market using a third it really is developing. The particular drugs just work in a restricted proportion associated with cystic fibrosis cases, however the triple is definitely expected to advantage 90% associated with patients. Assess Pharma’s Entire world Preview 2019, released final month, expected that Vertex’s triple mixture would earn more money than every other drug for virtually every condition within the pipeline: $20bn over the lifetime.

Vertex’s latest monetary results, for that second one fourth of 2019, show item revenues are usually up 25% from a year ago, with an embrace the anticipated revenue for the entire year through $3. 6bn to $3. 7bn.

Orkambi and the additional cystic fibrosis drugs manufactured by Vertex would be the first that will target the actual causes of the particular genetic ailment that clogs children’s and youthful adults’ lung area and reduces the length of lives. The fogeys of children whom could take advantage of the treatment are usually distressed by delay, conscious that kids do better the earlier they can obtain the drug.

Rob Lengthy, who has already been buying Orkambi privately meant for his nine-year-old son Aidan, says he could be appalled from the high costs of the medicines from a corporation making this kind of profits.

“It’s the obscene face associated with capitalism, in which a drug firm makes up the prices depending on what it believes it can escape with, ” he mentioned. “The existing system is damaged and not functioning. There must be an independent approach to fair assessment and joining arbitration to make sure lives are not really put just before profit. The current situation is definitely nothing in short supply of torture plus there is a EL convention towards that.

“Vertex is regularly considered a good outlier, also by the pharmaceutic industry, therefore the current scenario is intolerable. With no result in sight, just how can the government permit this impasse to continue. Up to now, over two hundred fifity have passed away who might have been helped. ”

NHS Britain said it had been still within negotiations using the company. “NHS has made 2 of the most nice offers from the kind for this company plus intensive function continues on a regular basis but the fastest way for individuals to get entry to Orkambi continues to be for Vertex to accept the offer plus engage with Good, ” mentioned a spokesperson.

“Vertex is definitely an extreme outlier in both prices and conduct. In fact , the particular pharmaceutical industry body mentioned the current provide represents precisely the sort of versatility industry desires and cautioned companies they can not just choose any cost they such as for a brand new medicine. ”

Vertex mentioned it disagreed with Hollis’s paper. “We have been persistent in our quest for a cure for cystic fibrosis plus invested considerably in this area whenever other companies may not because the danger was way too high, ” this said in the statement. “Vertex scientists been employed by for over two decades to do the thing that was once believed impossible—develop medications that deal with the underlying reason for cystic fibrosis.

“Since 2k, Vertex’s purchase in medication discovery r and d has totalled $11. 8bn. In fact , among 2012 plus 2017 the research and development expenses represented more than 70% in our total working expenses.

“The price of the medicines is founded on the value they will bring as well as the difference earning to patients’ lives, their own families and communities, as well as the substantial R&D expenditure we have designed to develop all of them and responsibility to finding upcoming treatments. Since our medications treat the actual cause of illness they not just treat the outward symptoms but also effect long-term development. ”

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